Perda de qualidade do sono e fatores associados em mulheres climatéricas / Loss of quality of sleep and associated factors among menopausal women

Resumo O objetivo deste artigo é identificar a prevalência de perda da qualidade do sono em mulheres climatéricas e os fatores associados. Estudo quantitativo, transversal e analítico, cujas variáveis foram investigadas por questionário estruturado/pré-testado e pelo Índice de Qualidade do Sono de Pittsburgh, em 819 mulheres climatéricas assistidas pela Estratégia Saúde da Família. Regressão de Poisson simples foi utilizada para triagem das variáveis (p < 0, 25). Para a modelagem hierarquizada foi utilizada a regressão de Poisson, adotando nível de significância de 5%. Identificou-se perda de qualidade do sono em 67% da amostra. Variáveis como idade avançada (RP = 1,09; IC = 1,03 - 1,16), sintomas climatéricos moderados e intensos (RP = 1,18; IC = 1,10 - 1,27), ansiedade moderada e grave (RP = 1,17; IC = 1,10 - 1,25), depressão moderada/grave (RP = 1,08; IC = 1,01 - 1,15) e artrite/artrose/reumatismo (RP = 1,07; IC = 1,01 - 1,14) demonstraram associações estatisticamente significativas com a perda de qualidade do sono. A perda de qualidade do sono foi altamente prevalente na população estudada. Os fatores associados à perda da qualidade do sono foram idade avançada, sintomas climatéricos de moderados a intensos, ansiedade e depressão moderada a intensa e presença de artrite/artrose/reumatismo.

Abstract The scope of this article is to identify the prevalence of the loss of quality of sleep and associated factors among menopausal women. It is a quantitative, cross-sectional and analytical study, the variables of which were investigated by applying a structured/pre-tested questionnaire and the Pittsburgh Sleep Quality Index with 819 menopausal women cared for under the Family Health Strategy. Simple Poisson regression was used to screen the variables (p < 0.25). For multiple analysis, Poisson regression was used based on a hierarchical model, at a significance level of 5%. Loss of quality of sleep was identified in 67% of the sample. Variables such as advanced age (PR = 1.09; CI = 1.03-1.16), moderate and severe menopausal symptoms (PR = 1.18; CI = 1.10-1.27), moderate to severe anxiety (PR = 1.17; CI = 1.10-1.25), moderate to severe depression (PR = 1.08; CI = 1.01-1.15) and arthritis/arthrosis/rheumatism (PR = 1. 07; CI = 1.01 - 1.14) revealed statistically significant associations with loss of quality of sleep. The loss of quality of sleep was highly prevalent in the population studied. Factors associated with loss of quality of sleep were advanced age, moderate to severe menopausal symptoms, moderate to severe anxiety and depression, and the presence of arthritis/arthrosis/rheumatism.

Frequency of depression and anxiety symptoms in mexican patients with rheumatic diseases determined by self-administered questionnaires adapted to the spanish language

Abstract Background The frequency of depression and anxiety symptoms in Spanish-speaking patients suffering from rheumatic conditions is unknown when using self-administered detection tools. Methods A single-center, cross-sectional survey including 413 patients (341 women) with well-defined rheumatic diseases was conducted. The patient health questionnaire-9 (PHQ-9) and generalized anxiety disorder (GAD)-7 questionnaires were used to detect depression and anxiety symptoms, respectively. Results A total of 193 patients (46.7%) reported depression symptoms, and increased PHQ-9 scores were more frequently observed in women than in men (23% vs. 13%; p = 0.038), particularly in association with osteoarthritis, fibromyalgia, Sjögren’s syndrome, and osteoporosis. From 88 patients (21.3%) with PHQ-9 scores ≥ 10 points (moderate-to-severe depression symptoms), 27 (30.6%) were previously diagnosed to have depression and only four were under antidepressant treatment. Anxiety symptoms were observed in 168 patients (40.6%) and classified as moderate-to-severe by elevated GAD-7 scores in 68 subjects (16.4%). Of them, 12 (17.6%) were previously diagnosed with GAD, but only 4 (5.8%) were under therapy. Conclusions An unexpected and unusually high frequency of undiagnosed depression and anxiety symptoms was found in rheumatic patients. Self-administered screening tools adapted to the Spanish language are useful and may help clinicians to suspect these conditions.

Associação entre doenças crônicas e força de preensão manual de idosos residentes em Florianópolis - SC, Brasil / Association between chronic diseases and handgrip strength in older adults residents of Florianópolis - SC, Brazil

Resumo O objetivo deste artigo é verificar a associação entre doenças crônicas e força de preensão manual (FPM) em idosos de Florianópolis, SC. Análise transversal de um estudo longitudinal de base populacional, com 599 idosos avaliados. A FPM foi verificada por meio de dinamômetro. As variáveis independentes incluíram 10 doenças crônicas e quedas. Foram realizadas análises de regressão linear simples e múltipla. No modelo final, a artrite/reumatismo/artrose (β:-1,27; IC95%: -2,55;-0,20) foi associada à menor FPM, enquanto a bronquite/ asma (β:1,61; IC95%:0,21;3,00) foi associada à maior FPM, nas mulheres. Para os homens, no modelo final, diabetes (β:-3,78; IC95%:-6,51;-1,05) mostrou associação com a menor FPM. Na análise de tendência, houve declínio da FPM com o aumento do número de doenças crônicas para ambos os sexos. Houve associação entre algumas doenças crônicas e a FPM, com diferenças entre os sexos. Torna-se imprescindível a reformulação de políticas de saúde direcionadas à manutenção da independência e autonomia da população idosa.

Abstract This paper aims to verify the association between chronic diseases and handgrip strength (HS) in the older adults of Florianópolis, SC. This is a cross-sectional analysis of a longitudinal population-based study. HS was measured by dynamometer. Independent variables included 10 chronic diseases and falls. Simple and multiple linear regression analyses were performed. In the final model, in women, arthritis/rheumatism/arthrosis (β: -1.27; 95%CI: -2.55; -0.20) was associated with lower HS and bronchitis/ asthma (β: 1.61, 95%CI: 0.21; 3.00) was associated with higher HS. Regarding men, in the final model, diabetes (β:-3.78; 95%CI: -6.51; -1.05) was associated with lower HS. The trend analysis evidenced a lower HS with increased number of chronic diseases in both genders. There was an association between some chronic diseases and HS, with differences between genders. ĩt is essential to overhaul health policies aimed at maintaining the independence and autonomy of the older adults population.

Signs and symptoms of rheumatic diseases as first manifestation of pediatric cancer: diagnosis and prognosis implications / Sinais e sintomas sugestivos de doenças reumáticas como primeira manifestação de doenças neoplásicas na infância: implicações no diagnóstico e prognóstico

ABSTRACT Objective: To assess the prevalence and describe the clinical, laboratory and radiological findings, treatment and outcome of children with cancer initially referred to a tertiary outpatient pediatric rheumatology clinic. Methods: Retrospective analysis of medical records from patients identified in a list of 250 new patients attending the tertiary Pediatric Rheumatology Clinic, Ribeirão Preto Medical School hospital, University of São Paulo, from July 2013 to July 2015, whose final diagnosis was cancer. Results: Of 250 patients seen during the study period, 5 (2%) had a cancer diagnosis. Among them, 80% had constitutional symptoms, especially weight loss and asthenia, and 60% had arthritis. Initially, all patients had at least one alteration in their blood count, lactate dehydrogenase was increased in 80% and a bone marrow smear was conclusive in 60% of patients. Bone and intestine biopsies were necessary for the diagnosis in 2 patients. JIA was the most common initial diagnosis. The definitive diagnosis was acute lymphoblastic leukemia (2 patients), M3 acute myeloid leukemia, lymphoma, and neuroblastoma (one case each). Of 5 patients studied, 3 (60%) are in remission and 2 (40%) died, one of them with prior use of steroids. Conclusion: The constitutional and musculoskeletal symptoms common to rheumatic and neoplastic diseases can delay the diagnosis and consequently worsen the prognosis of neoplasms. Initial blood count and bone marrow smear may be normal in the initial framework of neoplasms. Thus, the clinical follow-up of these cases becomes imperative and the treatment, mainly with corticosteroids, should be delayed until diagnostic definition.

RESUMO Objetivo: Avaliar a prevalência e descrever as principais manifestações clínicas, os exames complementares, o tratamento e a evolução de crianças com doenças neoplásicas atendidas inicialmente em um serviço terciário de reumatologia pediátrica. Métodos: Analisamos retrospectivamente o prontuário médico de pacientes com diagnóstico definitivo de neoplasia, identificados entre 250 casos novos atendidos no ambulatório de reumatologia pediátrica do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto-USP, de julho de 2013 a julho de 2015. Resultados: Dos 250 pacientes, cinco (2%) tiveram diagnóstico de neoplasia. Desses, 80% apresentavam sintomas constitucionais, principalmente perda de peso e astenia e 60% artrite. Inicialmente, todos apresentavam pelo menos uma série alterada no hemograma, 80% aumento da desidrogenase lática (LDH) e 60% mielograma confirmatório. Dois pacientes necessitaram de biópsia, óssea e de intestino, para o diagnóstico final. Artrite idiopática juvenil foi o diagnóstico inicial mais frequente. Os diagnósticos definitivos foram leucemia linfoide aguda (dois casos), leucemia mieloide aguda-M3, neuroblastoma e linfoma (um caso cada). Dos pacientes estudados, três (60%) estão em remissão. Dois pacientes foram a óbito (40%), um deles com uso prévio de corticoide. Conclusão: Os sintomas constitucionais e musculoesqueléticos comuns às doenças reumáticas e neoplásicas podem retardar o diagnóstico e consequentemente agravar o prognóstico das neoplasias. O hemograma inicial, assim como o mielograma, podem estar normais no quadro inicial das neoplasias. Dessa forma, o seguimento clínico evolutivo desses casos torna-se imperativo e o tratamento, principalmente com corticoides, deve ser retardado até definição diagnóstica.

Anticoncepción hormonal en mujeres jóvenes con enfermedades reumatológicas / Hormonal contraception in young women with rheumatic diseases

Antecedentes: Las enfermedades reumatológicas (ER) se presentan con mayor frecuencia en mujeres en edad fértil. Es durante este período que muchas mujeres consultan por trastornos de los flujos rojos, dismenorrea y prevención del embarazo. Objetivo: Realizar una puesta al día del uso de anticoncepción hormonal (AH) en mujeres jóvenes con ER, especialmente en las portadoras de lupus eritematoso sistémico (LES) y artritis reumatoide (AR). Método: Se revisó la literatura en Pubmed para los términos AH en ER, con especial énfasis en guías clínicas y ensayos clínicos aleatorizados. Resultados: El uso de AH en pacientes con LES inactivo o con actividad leve no ha mostrado un empeoramiento de la enfermedad. Tampoco existe evidencia categórica que demuestre un mayor riesgo trombótico en aquellas con anticuerpos antifosfolípidos negativos, para las cuales se recomienda el uso de cualquier tipo de AH. En pacientes con AR no se ha demostrado asociación del uso de AH y aumento de la actividad de la enfermedad. Además la interacción farmacológica entre AH y medicamentos reumatológicos es mínima. Existe escasa evidencia del uso de AH en mujeres menores de 18 años con ER. Conclusión: Basado en la evidencia disponible las pacientes con ER con anticuerpos antifosfolípidos negativos podrán utilizar AH según los criterios de la OMS, lo que abre las puertas a mayores alternativas terapéuticas y prevención de embarazo para estas adolescentes y mujeres jóvenes con ER.

Background: Rheumatologic diseases (RD) are most common in women of childbearing age. It is during this period that many women consult for menstrual disorders, dysmenorrhea and pregnancy prevention. Objective: To update the use of hormonal contraception (HC) in young women with RD. Method: Literature was reviewed in PubMed for HC and RD terms, with special emphasis on clinical guidelines and randomized clinical trials. Results: The use of HC in patients with inactive or mild activity systemic lupus erythematosus has not shown a worsening of the disease. Also, there is no evidence demonstrating greater thrombotic risk in those with negative antiphospholipid antibodies, for which the use of any type of HC is recommended. In patients with rheumatoid arthritis an association between use of HC and increases disease activity has not been demonstrated. In addition, there is minimal drug interaction between HC and rheumatologic drugs. There is little evidence of the use of HC in women less than 18 years with RD. Conclusion: Based on the available evidence the patients with RD and negative antiphospholipid antibodies could use HC according to WHO criteria, which leads to greater therapeutic alternatives and pregnancy prevention for these adolescents and young women with RD.

Manifestaciones reumaticas de las neoplasias / Rheumatical clinical manifestations of neoplasias

En este artículo se resaltan las manifestaciones clínicas reumáticas de las neoplasias, los síndromes paraneoplásicos musculoesqueléticos y en general los diversos síndromes reumáticos y su asociación con malignidad. De igual forma se hace énfasis en la importancia de tener en cuenta que los diversos síndromes reumáticos no deben en un inicio tener un estudio exhaustivo para neoplasias y que sólo debe realizarse en presentaciones atípicas, o que no respondan al tratamiento convencional o que de alguna forma tengan en su presentación algunas características específicas para neoplasias.

A Korean Rheumatic Diseases Screening Questionnaire

The aim of our study was to develop a Korean rheumatic diseases-screening questionnaire. The questionnaire was constructed based on American College of Rheumatology criteria for rheumatic diseases and a connective tissue diseases screening questionnaire. Two groups of patients were selected and completed the questionnaire: (i) those with osteoarthritis (n=46), rheumatoid arthritis (n=52), systemic lupus erythematosus (n=50), scleroderma (n=8), polymyositis or dermatomyositis (n=7), Sjogren's disease (n=4), and mixed connective-tissue disease (n=9) as case subjects; and (ii) those with fibromyalgia (n=8) and general disease without evidence of any rheumatic disease (n=72) as controls. Laboratory results were analyzed for correlation with actual data using kappa (kappa) statistics. Test-retest reliability was performed in 12 patients, and showed strong agreement between the first and second interviews (kappa=0.91). The sensitivity of the questionnaire ranged from 77.8 to 100%, and specificity ranged from 68.8 to 95.0%. Negative predictive values were very high in the general population, from 98.4 to 99.99%. The kappa statistic for agreement between laboratory items was 0.22-0.56, except for rheumatoid factor, antinuclear antibody test, and muscle enzyme level. We have developed a simple and sensitive Korean rheumatic diseases-screening questionnaire for the epidemiologic study of rheumatic diseases in Korea.

Síndromes e manifestações reumáticas em pacientes infectados pelo vírus da imunodeficiência humana (HIV) / Rheumatic Syndromes And opportunistic musculoskeletal infections in HIV infected patients

Os autores comentam as principais síndromes reumáticas e infecções oportunistas musculoesqueléticas nos pacientes infectados pelo HIV

Silicone breast implants, auto antibodies and rheumatic diseases

Objective: Systematic prospective study in six hundred and nineteen symptomatic woman with breast implants. Methods: To evaluate the symptoms and laboratory findings of patients with silicone breast implants. Results: The majority of the patients in our study presented with the atypical rheumatic syndrome (74,9 percent). A few with so called silicone disease. Various auto antibodies were found sometimes more than one in close to ten percent of the patients analysed. Conclusions: A systemic disease characterized by fatigue, cognitive dysfunction, muscle skeletal pain and the presence of auto antibodies in certain patients were observed in symptomatic brazilian woman with silicone breast implants.

Enfermedades reumáticas pediátricas

Se presenta el caso de un niño de cinco años de edad que consulta por primera vez por edema y dolor en maléolo interno izquierdo presentando posteriormente hematuria en el que se estudia una enfermedad reumática de origen autoinmune.

Antígenos de diferenciación leucocitaria / Antigens of leucocyte differentiation

Los antígenos de diferenciación leucocitaria son moléculas que se detectan en la membrana de las células derivadas de la médula ósea y que se expresan con un patrón característico en cada una de las subpoblaciones de leucocitos, en sus variados estadios de diferenciación celular. En la práctica diaria, los antígenos de diferenciación leucocitaria son detectados con el empleo de anticuerpos monoclonales de origen murino; con el uso de diversas técnicas de laboratorio y estos anticuerpos, es factible el detectar, cuantificar, aislar y eliminar subpoblaciones definidas de células, tanto in vivo como in vitro. El conocimiento actual de los antígenos de diferenciación leucocitaria ha tenido un gran impacto en el campo de la reumatología, ya que ha facilitado grandemente el estudio de la fisiopatología de diversas enfermedades reumáticas, principalmente las de origen autoinmune. Además, los anticuerpos dirigidos en contra de los antígenos de diferenciación leucocitaria pueden ser de gran utilidad en el seguimiento y terapia de diversas condiciones caracterizadas por la presencia de inflamación y daño a tejidos

Frecuencia del empleo de recursos no comprobados en el manejo de enfermedades reumáticas / Frequency of use of unproven remedies in rheumatic diseases

Objetivo. Determinar la frecuencia del empleo de recursos no comprobados (RNC) en pacientes con enfermedades reumáticas (ER). Pacientes y métodos. Estudiamos de manera prospectiva 80 pacientes que acudieron por primera vez a consulta de Reumatología y a todos se les aplicó de manera directa un cuestionario a propósito de 35 RNC tomados de la experiencia cotidiana de médicos, pacientes y público en general. Resultados. 58/80 pacientes fueron mujeres; las edades del grupo estudiado variaron de 13 a 83 años con promedio de 48.2 años; el tiempo de evolución varió de 1 mes a 20 años con promedio de 4.7 años; 13 pacientes fueron analfabetas y en los 67 restantes el promedio de escolaridad fue de 6.5 años. De los pacientes, 59/80 (73.75 por ciento) utilizaron RNC en algún momento de la evolución de su padecimiento; el número de RNC varió de 1 a 12 con promedio de 2.52 RNC por paciente, considerando el grupo total de 80 enfermos. Cuarenta pacientes utilizaron de 1.3 RNC, 14 usaron 10 o más RNC; 3 usaron de 7-9 RNC y 2 usaron 10 o más RNC. El análisis de diversas variables demográficas entre sí resultó compleja, encontrándose únicamente una correlación estadísticamente significativa entre mayor tiempo de evolución y mayor empleo de RNC (X2 = 58.42 con p < 0.001). Conclusiones. el empleo de RNC es muy frecuente en nuestro medio. Es necesario informar a los pacientes y la población general acerca de los recursos médicos comprobados con los que se cuenta en reumatología con el objeto de desalentar el empleo de los no comprobados y llamar la atención de las autoridades sanitarias sobre este problema

Eficacia de una dieta vegetariana en síndromes musculoesqueléticos dolorosos idiopáticos crónicos / Efficacy of a vegetarian diet in patients with primary fibromyalgia syndrome, myofascial pain syndrome and chronic lumbalgia

Objetivo. Evaluar la eficacia de un régimen dietético vegetariano en pacientes con Síndrome de Fibromialgia Primaria (SPF), Síndrome de dolor miofascial (SDMF) y lumbalgia crónica. Tipo de estudio. Ensayo clínico controlado. Material y métodos. Se estudiaron 18 pacientes de sexo femenino con SPF, SDMF y lumbalgia. Diez recibieron dieta vegetariana (DV) y ocho dieta normal (DN). Ambos grupos recibieron similar tratamiento farmacológico y fisioterápico. Se evaluó intensidad de dolor, capacidad funcional y calidad de vida en tiempo basal y posteriormente a intervalos mensuales por 3 meses. Resultados. Los pacientes asignados a DV tuvieron mayores calificaciones de intensidad de dolor que los asignados a DN a partir de los 30 días de tratamiento; no hubo diferencia entre ambos grupos en cuanto a capacidad funcional y calidad de vida. Conclusiones. El uso de una dieta vegetariana no parece ser eficaz en pacientes con SPF, SDMF y lumbalgia crónica

The clinical significance of cytoplasmic inclusions(CPI) in synovial fluid examination

The clinical significance of cytoplasmic inclusions(CPI) in synovial fluid(SF) examination was evaluated. We examined SF specimens collected from major rheumatology clinics in the Philadelphia area during the period of January to December 1995. Among 759 patients in the initial study group, 419 cases with established diagnoses and full synovial analyses were included. Their diagnoses and SF analysis results including leukocyte counts, differential counts and wet preparations were collected and analysed. Ninety seven of the 419 SF specimens were found to have CPI. CPI were found in SF from almost all rheumatic diseases. They were most likely to be found in inflammatory arthropathy including rheumatoid arthritis(RA, 46%), juvenile rheumatoid arthritis(JRA, 78%) and psoriatic arthritis(55%). On the contrary, CPI were least common in crystal-induced arthropathy among the inflammatory arthropathy. CPI were found 8 out of 98 gout cases(8%) and 2 among 53 calcium pyrophosphate dihydrate(CPPD) deposition disease(4%). In noninflammatory arthropathy, CPI were found in only 6 cases(6%) out of the 103 osteoarthritis(OA). In RA cases with non-inflammatory SF, 4 of the 20 SF(20%) had CPI while only 6% of OA SF had CPI. OA SF with CPI were all noninflammatory SF. In summary, CPI were a common finding on SF examination. CPI were more likely to be found in inflammatory arthropathy than noninflammatory. Among inflammatory arthropathy, CPI can favor non-crystal arthropathy than crystal arthropathy. Awareness of the presence of CPI is suggested as an addendum to routine SF analysis. Renewed investigation of the several types of CPI may add further to the understanding of joint disease.